Skip to content

You can upload your own datasets to EVpedia via this board.

You should provide your information of: Example link
1. Name
2. E-mail
3. Types of molecules
4. PubMed ID (optional)
5. EV sources
6. EV isolation strategy
7. High-throughput analysis strategy
8. Number of identified molecules
9. Whether you are willing to provide raw file for further analysis
In addition, it would be very helpful if you upload the list of molecules you identified by attaching file in tsv or Excel format. Example link ).

Thank you for helping EVpedia

Tau protein in ectosomes

2014.11.09 19:25

Luc Views:410895 Recommend:1

Name BUEE 
Type of molecule Protein 
PubMed ID (Optional) 24971751 
EV sources ectosomes and exosomes from primary neuronal cultures and brain 
EV isolation strategy Ultracentrifugation 
High-throughput analysis strategy No 
Number of identified molecules
Willing to provide raw data of high-throughput analysis? No 

Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760.