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Tau protein in ectosomes

2014.11.09 19:25

Luc Views:151209

Name BUEE 
E-mail luc.buee@inserm.fr 
Type of molecule Protein 
PubMed ID (Optional) 24971751 
EV sources ectosomes and exosomes from primary neuronal cultures and brain 
EV isolation strategy Ultracentrifugation 
High-throughput analysis strategy No 
Number of identified molecules
Willing to provide raw data of high-throughput analysis? No 

Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760.